Jiang Jing-y
2013
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0
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Journal
Chemical Research and Application
Abstract
To study the synthesis and optimize its technologies of rocuronium bromide,rocuronium bromide was synthesized from commercially available epiandrosterone through elimination,bromination,epoxidation,aminolysis,reduction,ring opening,acetylation and then allylation with allyl bromide. The target compound was identified by elemental analysis,MS and 1H-NMR,and the overall yield was 24. 77%. The improved after-treatment method was featured with low cost,easy operation procedure and improved productivity,and could be readily applied to scale-up production.