Zhou Min
2012
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Journal
Chemistry & Bioengineering
Abstract
The synthetic process of 7-methoxy-naphthalen-1-yl-acetonitrile was studied in this article,and the reaction conditions were optimized.Using 7-methoxy tetralone as raw material,7-methoxy-naphthalen-1-yl-acetonitrile was synthesized by addition with LiCH2CN,dehydrogenation with DDQ and dehydration with TsOH·H2O.The total yield of the target compound reached 57%,purity reached up to 98%.The structure of 7-methoxy-naphthalen-1-yl-acetonitrile was confirmed with IR and 1HNMR.