Liu An-chang
2012
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Journal
World Pesticides
Abstract
2-chloro-4,4,4-trifluoroacetoacetate was synthesized using trifluoro-acetoacetate as the primary material by bubbling chlorine,and then 2-methyl-4-(trifluoromethyl)-thiazole -5-carboxylic acid was prepared by the cyclization and hydrolysis reaction of 2-chloro -4,4,4-trifluoroacetoacetate and thioamide in acetonitrile solution.Then 2-methyl -4-(trifluoromethyl) thiazole -5-carboxylic acid reacted with thionyl chloride to give 2-methyl -4-(trifluoromethyl)thiazole -5-carboxylic acid chloride,and the compound was reacted with 2,6-dibromo-4-trifluoromethoxy aniline in toluene to give the thifuzamide in the yield of above 55.4%.