Z. Long
2007
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Journal
Periodical of Ocean University of China
Abstract
Rocuronium bromide was synthesized from epiandrosterone by tosylation and elimination to give 5α- androst-2-en-17-one,which was then subjected to bromination with Copper(Ⅱ)bromide,epoxidation,substi- tution,ring opening,reduction and acetylation to afford(2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16(1- Pyrrolidinyl)-androstane-3,17-diol 17-acetate,and finally allylation with allyl bromide.The chemical struc- tures of rocuronium bromide and its intermediate were confirmed by ~1H NMR,~(13)C NMR and MS.The total yield ratio of oroduction was 14.3 %.