Wang Ling-ya
2015
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Guangzhou Chemical Industry
Abstract
N,N-Dimethyl-4-nitrobenzylamine is an important intermediate for organic synthesis,and is widely used in medicine,pesticide and chemical fields. The process with methylene chloride as the reaction solvent,with the dimethylamine hydrochloride for auxiliary materials,and with the acid-binding agent of triethylamine,the substrate 4-nitrobenzyl bromide was dissolved with dichloromethane dropwise addition,the reaction temperature was 30 ℃,the reaction time was 30 min,the reaction yield was 94. 7%. The menthod on the basis of the traditional process of hydrobromide bromine preparation was improved agent bromide. This process route with a low production cost,simple operation,short reaction time,easy industrial production and environmentally friendly.