A. Katritzky, I. Ghiviriga
1995
Citations
0
Influential Citations
18
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
Application of the SIMPLE (secondary isotope multiplet NMR spectroscopy of partially labelled entities) technique to heteroaromatic tautomerism proves that N-(pyridin-2-yl)acetamide 1 exists in [2H]chloroform, [2H6]acetone or [2H6]benzene solutions as the amide tautomer-rotamer A-I. The corresponding amide tautomeric form of N-(pyridin-2-yl)benzamide 2 was also found in [2H]chloroform. These results confirm long-established patterns of heteroaromatic tautomerism, and illustrate the utility of SIMPLE in tautomerism studies.