Wang Zu-cheng
2001
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Quality indicators
Journal
Herald of Medicine
Abstract
Objective:To determine the efficacy and safety of sultopride hydrochloride injection in treating patients with psychiatric disorders. Methods:A Random, double-blinded control study was carried out. 150 patients who met the CCMD-Ⅱ criteria of schizophrenia, mood disorders, mental retardation and alcoholic disorders were recruited for the study. 100 patients were treated wit sultopride hydrochloride injection and the others with sulpiride hydrochloride injection(100-300 mg·d -1 ) for one week. The efficacy was assessed by brief psychiatric rating scale (BPRS) and bech-rafaelsen mania scale (BRMS). The safety was assessed by treatment emergent symptom scale(TESS). Results:The BPRS agitation score, The BRMS score and the reduction of BRMS score were significantly different between the two groups(P0.01, 0.05 and 0.01, Respectively). No difference in the total score of TESS was revealed between the two groups. Conclusion:Sultopride hydrochloride injection is an effective and safe agent for the treatment of patients with excitement symptoms.