Ye Wen-cai
2010
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Journal
Journal of Shantou University Medical College
Abstract
Objective:To study the optimal synthetic route for fagomine.Method:The target compound was synthesized via multiple steps including Swern oxidation,Aldol reaction and reduced amination by applying 3-aminopropyl alcohol and 1,2-dihydroxyacetone as starting materials.Results:Fagomine had been synthesized by four-step process.The structure was confirmed by nuclear magnetic resonance and electrospray ionization mass spectrometry.Conclusion:Four-step process has been developed for the synthesis of fagomine.The product will be used in the further structural modification.