Yasser M Loksha, E. Pedersen, A. El‐Barbary
Jul 1, 2003
Citations
0
Influential Citations
6
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
4-tert-Butyl-1,3-dihydroimidazol-2-ones and 1,3-dihydroimidazol-2-thiones were synthesized from 1-amino-3,3-dimethylbutanone and subjected to alkylation reactions. The latter compounds were S-alkyl-ated with iodoacetamide under alkaline conditions. The N1 N3-unsubstituted derivative was iodinated and subsequently alkylated with alkylation reagents which previously have been used for the synthesis of anti-HTV active imidazoles. Unfortunately, the present products were devoid of activity against HTV.