A. Terada
Nov 1, 1966
Citations
0
Influential Citations
1
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
3-Chloromethyl-4-chloro-1,2-diphenylbutan-2-ol was obtained by a Grignard reaction of 2-benzoyl-1,3-dichloropropane using benzyl chloride, which was turned into 2-benzyl-2-phenyl-3-chloromethyl-trimethylene oxide by the alkali dehydrochlorination. Heating this oxide with an excess of piperidine at 170°C for 22 hr. gave 2-benzyl-2-phenyl-3-piperidinomethyl-trimethylene oxide and a small amount of 1,2-diphenyl-3-piperidinomethyl-2,4-butanediol. The same procedures with morpholine gave 2-benzyl-2-phenyl-3-morpholinomethyl-trimethylene oxide; with ethanolic dimethyl amine, however,afforded only 1,2-diphenyl-3-dimethylamino-methyl-2,4-butanediol.