S. Wallace, Jian Li, R. Nation
Jan 7, 2008
Citations
1
Influential Citations
69
Citations
Quality indicators
Journal
Antimicrobial Agents and Chemotherapy
Abstract
ABSTRACT The relative nephro- and neurotoxicity of colistin methanesulfonate (CMS) was investigated with rats during 7 days of intravenous administration in regimens mimicking twice- and once-daily dosing of a clinically relevant dose for humans. Histological examination revealed more-severe renal lesions with the regimen corresponding to once-daily dosing, indicating that the potential for renal toxicity may be greater with extended-interval dosing.