M. Amano
2016
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Abstract
Sauvigine is a peptide hormone, first isolated from the skin of the South American frog Phyllomedusa sauvagei in 1980, with adrenocorticotropic hormone (ACTH) releasing activity and antidiuretic activity. The SVG of Phyllomedusa sauvagei (PS-SVG) consists of 40 aa residues with an amidated C-terminus. The sequence identity of PS-SVG with human CRH is 63%. The sequence identity of PS-SVG with carp urotensin-I, human urocortin-I, human urocortin-II, and human urocortin-III is 50%, 35%, 20%, and 25%, respectively. SVG stimulates ACTH release from the pituitary of rats and goldfish. SVG stimulates α-melanocyte-stimulating hormone and β-endorphin release from the pars intermedia of the pituitary in Xenopus. SVG may be involved in chemical defense on the skin.