T. Hökfelt, J-O. Kellerth, G. Nilsson
Nov 28, 1975
Citations
8
Influential Citations
1,017
Citations
Quality indicators
Journal
Science
Abstract
Antibodies to substance P with a high titer have been produced and used in immunohistochemical studies on the peripheral and central nervous system of the rat and the cat. Evidence was obtained for the localization of substance P in a certain population of primary sensory neurons, probably small nerve cells with unmyelinated processes. Substance P or a peptide similar to it was also observed in cell bodies in the medial habenula and in probable nerve terminals in many brain areas. The results give morphological support for a transmitter (or modulator) role of substance P in the nervous system.