R. Whomsley, E. Fernández, P. Nicholls
Mar 1, 1993
Citations
0
Influential Citations
37
Citations
Journal
The Journal of Steroid Biochemistry and Molecular Biology
Abstract
Substituted 1-[(benzofuran-2-yl)-phenylmethyl]-imidazoles are a new class of potent aromatase inhibitor with in vitro IC50 values < 10 nM for certain members using human placental enzyme. At a dose of 2 mg/kg in PMSG-stimulated rats, selected compounds effectively reduce the oestradiol levels by 82-98%.