M. Missbach, E. Altmann, L. Widler
May 1, 2000
Citations
1
Influential Citations
37
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
5,7-Diphenyl-pyrrolo[2,3d]pyrimidines represent a new class of highly potent inhibitors of the tyrosine kinase c-Src (IC50 < 50 nM) with specificity against a panel of different tyrosine kinases. The substitution pattern on the two phenyl rings determines potency and specificity and provides a means to modulate cellular activity.