C. Beddell, P. Goodford, G. Kneen
Jun 1, 1984
Citations
5
Influential Citations
110
Citations
Quality indicators
Journal
British Journal of Pharmacology
Abstract
1 Substituted benzaldehydes have been designed to bind preferentially to the oxy conformation of human haemoglobin at a site between the amino terminal residues of the α‐subunits. Such compounds should stabilize the oxygenated form of haemoglobin and thereby increase its oxygen affinity. 2 The compounds produce the expected effect, left‐shifting the oxygen saturation curve of dilute haemoglobin solutions and of whole blood, although the binding pattern to haemoglobin is more complex than envisaged by the design hypothesis. 3 The predicted best compound is also a potent inhibitor, at low oxygen pressure, of the sickling of erythrocytes from patients homozygous for sickle cell disease, and may prove to be a clinically useful anti‐sickling agent.