J. Bream, H. Lauener, C. Picard
Oct 1, 1975
Citations
0
Influential Citations
23
Citations
Journal
Arzneimittel-Forschung
Abstract
The synthesis of a new series of phenylacetylguanidines is described. Several of them exhibited high antihypertensive activity in the rat. The most potent member of the series is N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride [2,6-dichlorophenylacetylguanidine hydrochloride, compound 19], which is now in clinical study under the clinical code number BS 100-141. The structure-activity relationships in this class of compounds are discussed.