L. Brockunier, Jiafang He, L. Colwell
Sep 20, 2004
Citations
1
Influential Citations
79
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Incorporation of a fluorophenyl beta-amino amide moiety into piperazine screening lead 2 has resulted in the discovery of a structurally novel series of potent and selective DP-IV inhibitors. Simplification of the molecule and incorporation of multiple fluorine atoms on the phenyl ring has provided low molecular weight analogs such as compound 32, which is a 19nM DP-IV inhibitor with >4000-fold selectivity over QPP.