M. Abass, Aisha S. Mayas
2007
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0
Influential Citations
9
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Journal
Heteroatom Chemistry
Abstract
Alkylation of 2-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one (1) was investigated under solid–liquid phase transfer catalysis conditions (PTC), using tetrabutylammonium bromide and potassium carbonate. The reaction with alkyl halides led to the formation of various 2-alkoxy products, in fair yields. Reaction of compound 1 with epichlorohydrin and chloroacetonitrile, under the same PTC conditions, afforded novel O1,O3-disubstituted glycerol and oxazolopyridopyrimidone betaine derivatives, respectively. Some 3-halo-, 3,3-dihalo, and/or 2,3-dihalopyrido[1,2-a]pyrimidines were also prepared using different halogenating agents at different reaction conditions. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:19–27, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20245