Y. Gong, Katsuya Kato, H. Kimoto
2000
Citations
0
Influential Citations
11
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
A number of α-(trifluoromethyl)heteroarylmethanols 2a—c are conveniently obtained in good yields by substitution of pyrole, furan, and thiophene with trifluoroacetaldehyde ethyl hemiacetal (TFAE); 2b and 2c are formed only in the presence of a catalyst such as ZnCl2. Analogous methanols 8a and 8b are also prepared by catalytic substitution of uracils with TFAE in moderate yields.