T. Shoji, Shokaku Kim, Keisuke Yamamoto
Dec 11, 2014
Citations
0
Influential Citations
31
Citations
Journal
Organic letters
Abstract
An efficient method for modifying a proline moiety through anodic carbon-carbon bond cleavage is developed. Use of the 2,4,6-trimethoxyphenyl (TMP) moiety as a leaving group at the 5-position allows the incorporation of various functional groups for modification in both the N- and C-terminal direction due to the stability of the N1-C5-C linkage. This approach also enables anodic substitution reactions using reactants with lower oxidation potential compared to N-carbonyl bonds.