Kazutoshi Sugawara, T. Hashiyama
May 21, 2007
Citations
0
Influential Citations
6
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Reaction of chiral cis - and trans -6-( tert -butyldimethylsilyloxy)-3,6-dihydro-2 H -pyran-3-yl acetates with various nucleophiles (allyltrimethylsilane, bistrimethylsilylacetylene, benzyl alcohol, benzyl carbamate etc.) in the presence of a Lewis acid gave the corresponding 2,3-unsaturated pyran derivatives in good to excellent yield with trans selectivity. Application to the synthesis of NK 1 antagonist is also described.