Yang Wang, Ying Wang, Qian Zhang
Mar 28, 2017
Citations
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Influential Citations
22
Citations
Journal
Organic chemistry frontiers
Abstract
A highly site-selective oxidative C–H sulfonylation method for 8-acylaminoquinolines and anilides with sulfonyl chlorides has been developed, which provided C5-sulfonylated quinolines and para-sulfonylated anilides respectively. Good functional group compatibility was showed in both amides and sulfonyl substrates. This method was only mediated by using a hypervalent iodine reagent PhI(OPiv)2 under mild conditions without any metallic catalyst or extra additives, which would provide a novel and facile methodology for synthesis of sulfone compounds.