Henry G. Mautner, Eva Bartels, George D. Webb
Feb 1, 1966
Citations
0
Influential Citations
37
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract Studies using the isolated single cell electroplax preparation indicated that the hydrolysis products of acetylthiocholine and acetylselenocholine, cholinethiol and cholineselenol, are powerful depolarizing agents. The activity of cholinethiol was greater at pH 6 than at pH 9. Methylation to form methylthiocholine and methylselenocholine increased activity further. Choline disulfide and choline diseleaide were antidepolarizing blocking agents. Differences between the active site of the depolarizing receptor and that of acetylcholinesterase are discussed.