J. Hoult, P. Moore
Sep 1, 1978
Citations
0
Influential Citations
75
Citations
Quality indicators
Journal
British Journal of Pharmacology
Abstract
Sulphasalazine is a potent and selective inhibitor in vitro of prostaglandin 15‐hydroxydehydrogenase in rabbit colon (ID5() = 50 μm) and in several other organs of different species, but does not inhibit prostaglandin A‐13 reductase or microsomal prostaglandin synthesis from arachidonic acid. It is suggested that this action may underly the therapeutic usefulness of sulphasalazine in ulcerative colitis for the prevention of relapse.