M. Friedman, V. Sanders, S. Woods
May 1, 1976
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
Groups of rats were pretreated with nitrososarcosine (NS), diethylnitrosamine (DEN), or dibutylnitrosamine (DBN) in order to observe potential effects on dimethylnitrosamine (DMN) toxicity and metabolism. NS and DEN completely suppressed DMN-induced inhibition of liver protein synthesis while the case with DBN was not as clear. DMN metabolism was effected by suppression of DMN demethylase activity, and an inhibition of RNA, DNA, and protein methylation by [14C]DMN by each nitroso compound.