Y. Mizushima
Mar 15, 1979
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Influential Citations
11
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Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract The effect of betamethasone 17,21-dipropionate, a potent synthetic glucocorticoid, on the glycogenic actions of cortisol and insulin was examined with fetal rat liver in organ culture. This steroid itself had no glycogenic action, unlike betamethasone or cortisol. To the contrary, at 10 −7 M, it suppressed completely the glycogenic action of cortisol (10 −7 M) and was suppressive even at 10 −9 M. Cortisol-induced glycogen accumulation was interrupted upon addition of betamethasone 17,21-dipropionate. The glycogenic action of cortisol was exhibited in explants preincubated with betamethasone 17,21-dipropionate upon replacement of the medium with one containing cortisol only. Betamethasone 17,21-dipropionate partially suppressed insulin-induced glycogen accumulation when added simultaneously with insulin (4.0 μg/ml), but could not interrupt such glycogen accumulation already in progress.