Carla Serri, B. Gennaro, Lilia Catalanotti
Apr 1, 2016
Citations
0
Influential Citations
32
Citations
Quality indicators
Journal
Microporous and Mesoporous Materials
Abstract
Abstract This work aimed to investigate the possible use of phillipsite (PHI) and chabazite (CHA), superficially modified with the cationic surfactant cetylpyridinium chloride (CP), for the controlled release of diclofenac sodium (DS) and compare them with the commercial clinoptilolite (CLI). Zeolites were characterized by confocal scanning laser microscopy (CLSM), powder X-ray diffraction and laser light scattering (LS). Furthermore, drug loading, powder flowability and in vitro drug release kinetics in simulated intestinal fluid (SIF), were investigated to assess the relationship between rock mineralogy and their pharmaceutical properties. Results showed that surfactant-modified natural zeolites (SMNZ)-CLI powder presents the best flow properties, followed by SMNZ-PHI and SMNZ-CHA. DS loading was very rapid (