R. Li, Z. Wan, A. Wang
Oct 1, 2004
Citations
0
Influential Citations
13
Citations
Quality indicators
Journal
Mycoses
Abstract
The antifungal susceptibility of isolates from Chinese dermatomycosis patients to amorolfine was investigated following National Committee for Clinical Laboratory Standards (NCCLS) protocols. In total, 383 isolates were tested, including 132 strains from tinea pedis, 148 strains from tinea corporis/cruris, and 103 strains from onychomycosis. The minimum inhibitory concentration (MIC) of amorolfine against dermatophytes ranged from 0.01 to 0.08 μg ml−1. The MIC50 and MIC90 of amorolfine for Trichophyton rubrum were both equal to 0.04 μg ml−1; for T. mentagrophytes these MICs were 0.04 μg ml−1 and 0.08 μg ml−1 respectively; and for Epidermophyton floccosum they were 0.02 μg ml−1 and 0.04 μg ml−1 respectively. The MIC range of amorolfine against Candida parapsilosis was 0.5–16 μg ml−1. MIC50 and MIC90 for C. parapsilosis were 0.5 and 2 μg ml−1. MIC ranges of amorolfine against Scopulariopsis spp. and Acremonium spp. were 0.5–4 and 2–8 μg ml−1, respectively. Candida albicans, Fusarium solani and Aspergillus flavus required relatively higher concentrations of amorolfine to inhibit their growth (MIC 0.125–64 μg ml−1, MIC50 and MIC90 were 4 and 64 μg ml−1). The results demonstrated that amorolfine is the only topical agent that has such a potent antifungal activity and a broad spectrum against a wide range of pathogenic fungi.