W. Davis, R. F. Borne, R. Hackett
Jun 16, 1980
Citations
0
Influential Citations
8
Citations
Quality indicators
Journal
Life sciences
Abstract
Abstract The acute median lethal dose (LD50) was determined in rats (p.o.) and mice (i.p.) for phencyclidine (PCP) or 1-piperidinocyclohexanecarbonitrile (PCC) individually and in combination. The LD50 (mg/kg) of PCP was 2.3 or 2.5 times higher than the LD50 of PCC in mice or rats, respectively. For mice, combinations (8:1 or 4:1) of PCP + PCC showed additive synergism, while in rats a 2:1 combination caused sub-additive synergism. Dogs receiving an intravenous infusion of PCP + PCC (4:1) died at a one-third lower dosage of PCP than when PCP was given alone. Prior treatment with NaNO2 significantly elevated the i.p. LD50's in mice for PCC alone or PCP + PCC (3:1) as it did for KCN. These data support the inference that toxicity from PCC arises primarily from the cyanide ion which it releases. The possibility of a toxic synergism in the course of human exposure to PCC-contaminated “street PCP” is raised.