C. Moussebois, J. Heremans, Robert Merényi
Jan 26, 1977
Citations
0
Influential Citations
6
Citations
Journal
Helvetica Chimica Acta
Abstract
Synthesis of two phenolic amino acids containing the 1,2,4-oxadiazole ring The synthesis of α-amino-β [3-(p-hydroxyphenyl)-1,2,4, oxadiazol-5-yl]propionic acid (9) and its β-amino isomer (10) (see scheme 3) is reported. By condensation of p-benzyloxy-benzamide oxime and N-benzyloxycarbonyl asparagine the derivatives 4 and 5 (see scheme 1) are obtained leading after deprotection to 9 and 10. The synthesis of N-carboxyanhydride of 4 (6) and its corresponding amino acid (7) and amide (8) is also described.