G. Dewynter, Jean-Louis Montero, Bernadette Agoh
Sep 1, 1991
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Journal
Phosphorus Sulfur and Silicon and The Related Elements
Abstract
Abstract A partir de l'isocyanate de chlorosulfonyle (C.S.I.), reactif Nectrophile bifonctionnel, on accede a des 2-chloroethylsulfonylurees et des 2-chloroethoxysulfonylurees, sur le modele de nitrososourees aux proprietes oncostatiques. Les composes obtenus, alkylants et carbamylants potentiels, ont ete etudies par IR, RMN, spectrometrie de Masse et diffraction des RX, et ont ete soumis a une evaluation biologique. Nitrosoureas, a major class of cytotoxics and oncostatics, present in clinical uses some secondary iatrogenic effects (e.g., thrombopeniae, myelotoxicity, mutagenicity …). In the field of research of alkylo-carbamoyling non-nitrosed compounds, are presented here two news series which associate ureido group with 2-chloroethyl substituant. Both title's compounds are synthetized from chlorosulfonyl isocyanate (C.S.I.), by regioselective methods. The structure are established by IR, NMR 1H and 13C, Mass spectrometry and RX diffraction data. The biological evaluation towards L1210 does not show si...