O. Abdelmageed, R. Duclos, R. Griffin
May 1, 1989
Citations
0
Influential Citations
7
Citations
Journal
Chemistry and Physics of Lipids
Abstract
Abstract Improved syntheses of 1,2-di-O-hexadecyl-sn-glycero-3-phosphoethanolamine and 1,2-di-O-hexadecyl-sn-glycero-3-phosphocholine were performed in 71% and 57% overall yields, respectively. Reported reactions which have been greatly improved include the dialkylation of 3-O-benzyl-sn-glycerol, the hydrogenolysis of the 3-O-benzyl-sn-glycerol derivative, and the quaternization of the sn-glycero-3-phosphoethanolamine to the corresponding sn-glycero-3-phosphocholine. Several 2H-, and 13C-labeled analogs of 1,2-di-O-hexadecyl-sn-glycero-3-phosphocholine were then prepared by the appropriate modifications of our synthetic sequence.