S. Kamiya, M. Tanno
Aug 25, 1975
Citations
0
Influential Citations
2
Citations
Journal
Chemical & pharmaceutical bulletin
Abstract
1-Alkoxy-3, 6-dimethyl-5-nitro-4 (1H)-pyridazinones (VIIa, b) were synthesized by the nitration of 3, 6-dimethyl-4-hydroxypyridazine 1-oxide (IV), followed by alkylation with alkyl halides. The catalytic hydrogenation of the nitro compound VIIa gave 1-methoxy-3, 6-dimethyl-5-amino-4(1H)-pyridazinone (IX). 1-Methoxy-3, 6-dimethyl-5-bromo-4 (1H)-pyridazinone (XI) was similarly synthesized by the bromination of IV, followed by alkylation.