R. Srivastava, G. Kabalka
Dec 1, 1997
Citations
0
Influential Citations
24
Citations
Journal
Journal of Organic Chemistry
Abstract
The syntheses of unnatural amino acids, 1-amino-3-[2-(7-(2-hydroxyethyl)-1,7-dicarba-closo-dodecaboran(12)-1-yl)ethyl]cyclobutanecarboxylic acid (2) and its nido analog 1-amino-3-[2-(7-(2-hydroxyethyl)-1,7-dicarba-nido-dodecaboran(12)-1-yl)ethyl]cyclobutanecarboxylic acid (3) were achieved. The key steps in the syntheses of 2 and 3 involved the sequential dialkylation of m-carborane and an intramolecular ethoxide ion mediated cage degradation process.