Z. Brzozowski, J. Sławiński
Aug 17, 2004
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ChemInform
Abstract
A series of 1-(arylsulfonyl)-3-(2,2-dimethoxyethyl)ureas (2a-e) was obtained by the reaction of 1-(phenylsulfonyl)ureas (1a-e) with aminoacetaldehyde dimethyl acetal in boiling dioxane. Cyclocondensation reactions ofthe 1-(arylsulfonyl)-3-(2,2-dimethoxyethyl)ureas (2a-e) in 98% H 2 SO 4 gave the appropriate 1-(arylsulfonyl)-(1H,3H)-imidazol-2-ones (3a-e) in good yields. The subsequent reaction of 3a with methanesulfonyl- or 4-nitrophenylsulfonyl chlorides furnished the 3-(R 4 -sulfonyl) derivatives 4 and 5, respectively. Preliminary screening data indicated that the compounds 3c-e, 4 and 5 were inactive against three selected human tumor cell lines derived from Breast cancer (MCF7), Lung cancer (NCI-H460) and CNS cancer (SF-268).