M. Kluge, D. Sicker
Nov 1, 1996
Citations
0
Influential Citations
10
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
2-Amino-2H-1,4-benzoxazin-3(4H)-one 3, 2-amino-2H-1,4-benzothiazin-3(4H)-one 4, 2-mercapto-2H-1,4-benzoxazin-3(4H)-one 7, and 2-mercapto-2H-1,4-benzothiazin-3(4H)-one 8 representing aza and thio analogues of the natural product's aglucone Blepharigenin (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one) from Gramineae and Acantnaceae species have been synthesized for the first time from their 2-bromo precursors 1 and 2. Attempts to similarly prepare the 4-hydroxy derivatives of 7 and 8, which would represent new thio analogues of the naturally occurring cyclic hydroxamic acid, 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one, have failed.