Jianguang Zhou, Qun Jiang, Peng Fu
Aug 25, 2017
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0
Influential Citations
4
Citations
Journal
The Journal of organic chemistry
Abstract
An alternative synthesis of 4-(heteroaryl)cyclohexanones is described featuring a palladium-catalyzed ester α-arylation followed by decarboxylation. The substrate scope is broad with a wide range of heteroaryl halides. In particular, the reaction robustness is demonstrated by the synthesis of >10 g of 4-(pyrazin-2-yl)cyclohexanone with 85% overall yield.