J. Rossignol, A. Stachulski
Jan 1, 1999
Citations
0
Influential Citations
4
Citations
Journal
Journal of Chemical Research
Abstract
The thiazole derivative nitazoxanide 1, first described by Rossignol, I is a broad-spectrum antibacterial and antiparasitic agent, particularly efficacious against anaerobic bacteria/ and as an anthelmintic and antiprotozoal agent.v" The desacetyl metabolite of 1, tizoxanide 2, is itself a potent antibacterial and antiparasitic agent." Further metabolism of 2 leads to the glucuronide 3 and sulfate 4 conjugates. In this paper, we describe the conversion of 1 to 2 and a convenient synthesis of 3, both to test for any remaining bioactivity and as an analytical standard.