F. Havaldar, Navin Khatri
2006
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Journal
Heterocyclic Communications
Abstract
4-(Chlorosulfonyl) benzoic acid was condensed with diethyl amine to afford 4(diethylsulfamoyl) benzoic acid 1 which was esterified to obtain methyl ester 2. The condensation of compound 2 with hydrazine hydrate gave hydrazino derivative 3. This intermediate undergoes cyclization with carbon disulphide and potassium hydroxide to yield substituted l,3,4-oxadiazolin-5thione 4. Aminomethylation of 4 using different amines furnished 4-substituted aminomethyl-2-(4'diethylsulphonamide phenyl)-l,3,4-oxadiazolin-5-thiones 5a-e. The structure of the newly synthesized compounds have been established by analytical and spectral data. These compounds have also been screened for their biological activity.