Sanghee Kim, Eun Young Kim, H. Ko
Oct 1, 2003
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Influential Citations
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Journal
Synthesis
Abstract
The efficient and practical asymmetric syntheses of the biologically important (S)-2-amino-8-oxodecanoic ester and its ho- mologues have been achieved employing the Schollkopf chiral aux- iliary. Carbon-carbon bond formation between the appropriate alkyl bromide and the LDA generated anion of the Schollkopf auxiliary, followed by hydrolysis provided the desired methyl ester of a long- chained keto amino acid in high yield with high selectivity.