I. Bidd, David J. Kelly, P. M. Ottley
1983
Citations
0
Influential Citations
17
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
The conversion of cyclododecanone by convenient, non-hazardous, and high-yielding reactions into a set of useful C12-bifunctional intermediates is described. Baeyer–Villiger oxidation and hydrolysis give a hydroxy acid, successively converted into the bromo acid, bromo alcohol, crude bromo aldehyde, pure bromo aldehyde ethylene acetal, and pure bromo aldehyde. Preferred reagents for the transformation CO2H → CHO are borane–dimethyl sulphide followed by dimethyl sulphoxide–oxalyl dichloride–triethylamine.