M. Nath, H. Singh, G. Eng
Oct 1, 2009
Citations
2
Influential Citations
15
Citations
Journal
Inorganic Chemistry Communications
Abstract
Abstract Novel organotin(IV) derivatives of guanine of the general formula, R2Sn(HGu)2 (where, R = Me (1), n-Bu (2) and Ph (3)) have been synthesized by the reaction of R2SnCl2 with sodium salt of guanine (H2Gu or 2-amino-6-hydroxypurine). The IR spectral studies suggest that guanine acts as a monobasic ligand coordinating through N(9) after its deprotonation. The weak bonding through C(6) O may also be evidenced, whereas 119Sn Mossbauer data suggest that the coordination number of tin is superior than four. The polyhedron around tin in R2Sn(HGu)2 is distorted trigonal–bipyramidal or pseudo-tetrahedral involving very weak interaction from C O group of neighboring molecule leading to polymerized structure. All the compounds exhibited potent anti-inflammatory activity with no appreciable side effects on blood pressure as evidenced by their very mild cardiovascular activity.