I. Nitta, S. Fujimori, Haruyama Toshio
Mar 1, 1985
Citations
0
Influential Citations
17
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
An efficient synthesis of 17α,21-dihydroxypregna-1,4-diene-3,20-dione 17,21-diacetate (10) from androsta-1,4-diene-3,17-dione (1), a biodegradation product of cholesterol, is described, which involves the ethynylation of the 17-ketone, the epimerization of the 17α-ethynyl group and conversion of the ethynyl group to the 20-keto pregnane. Overall yield is relatively high (about 54%) and 10 will be a potential intermediate for prednisolone.