B. Day, C. Kangani, K. Avor
Jun 21, 2002
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0
Influential Citations
11
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract Two new highly stereoselective routes to (2 R ,3 S ,4 R )-3-( tert -butyldimethylsilanyloxy)-2,4-dimethyl-5-oxopentanoic acid methoxymethylamide, an important intermediate in natural product synthesis, are described. Both schemes are considerably shorter and less expensive than methods previously reported. The title compound was then converted to direct precursors of C1–C7 and C17–24 fragments of the potent microtubule stabilizer (+)-discodermolide.