Y. Ono, A. Kawase, H. Watanabe
Dec 1, 1998
Citations
1
Influential Citations
29
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry
Abstract
Analogues related to 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effects of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity.