D. Pons, M. Savignac, J. Genêt
1990
Citations
0
Influential Citations
36
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Both enantiomers of (S) 1 and (R) 2 isoserine as well (D) 3 and (L) 4 allothreonine are prepared optically pure in three steps by asymmetric Sharpless epoxidation of crotyl and allylic alcohols into 7 - 10 followed by an improved RuCl 3 /NaIO 4 /water oxidation procedure to low molecular weight glycidic acids 11 - 14 and epoxide opening by ammonia with (20 – 33%) overall yields.