A. Avenoza, J. H. Busto, F. Corzana
Jan 12, 2004
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Journal
Tetrahedron-asymmetry
Abstract
Abstract Herein we describe the synthesis of the two enantiomerically pure 3-amino-2-hydroxy-2-methylpropionic acids––(S)- and (R)-α-methyl isoserines––starting from the chiral diols (S)- and (R)-2,3-dihydroxy-N-methoxy-2,N-dimethylpropionamides, respectively, which were obtained by Sharpless asymmetric dihydroxylation (AD) of the olefin N-methoxy-2,N-dimethylacrylamide with AD-mix α or β as chiral catalytic ligands.