Y. Hamada, I. Takeuchi, M. Hirota
Sep 25, 1971
Citations
0
Influential Citations
10
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
1, 8-Naphthyridines (III to VI) were synthesized in a high yield by the reaction of 2-aminopyridines with glycerol, in the presence of sodium m-nitrobenzenesulfonate, in sulfuric acid. Methylation of naphthyridines with dimethyl sulfoxide in the presence of sodium hydride or potassium tert-butoxide afforded their monomethyl or dimethyl compounds. This methylation with methylsulfinyl carbanion was examined from the Huckel molecular orbital method and its result agreed well with experimental results.