J. Kehler, B. Ebert, O. Dahl
1998
Citations
0
Influential Citations
12
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
Piperidin-4-ylphosphinic acid, methyl(piperidin-4-yl)phosphinic acid and piperidin-4-ylphosphonic acid analogues of the GABAA agonist piperidin-4-ylcarboxylic acid (isonipecotic acid) were synthesised. The acid groups were introduced using a sequential Pudovik addition followed by a Barton deoxygenation procedure and finally followed by acidic hydrolysis. The mild and efficient procedure gave the target amino acids in good yields.